FPS-ZM1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1125 | Check With Us |
: Cat #: V2810 CAS #: 945714-67-0 Purity ≥ 98%
Description: FPS-ZM1 is a potent and high-affinity RAGE specific blocker with Ki value of 25 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 327.85 |
|---|---|
| Molecular Formula | C20H22ClNO |
| CAS No. | 945714-67-0 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMrr |
| Water: N/Arr | |
| Ethanol: N/A | |
| SMILES Code | C1CCC(CC1)N(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)Cl |
| Synonyms | FPS-ZM 1; FPS ZM-1; FPSZM 1; FPS-ZM1; FPS ZM1; FPSZM1 |
| Protocol | In Vitro | FPS-ZM1 inhibits Aβ/RAGE binding in CHO cells with approximately 2-fold higher affinity than its parent molecule FPS2. FPS-ZM1 inhibits the binding of other known RAGE ligands to sRAGE, including S100 calcium-binding protein B and amphoteric proteins. FPS-ZM1 is more effective than FPS40 in reducing Aβ1-induced elevated levels of BACE2 mRNA and protein, as well as the production of sAPPβ, an APP lysate of BACE1, indicating BACE1 activity |
|---|---|---|
| In Vivo | FPS-ZM1 is non-toxic to mice and easily crosses the blood-brain barrier. In old age overexpressing human Aβ precursor proteins .APPsw/0 In mice, FPS-ZM1 inhibits RAGE-mediated circulating Aβ40 influx, a transgenic mouse model of AD with a defined Aβ pathology, and Aβ42 into the brain. In the brain, FPS-ZM1 binds specifically to RAGE, which inhibits β-secretase activity and Aβ production, and inhibits microglial activation and neuroinflammatory responses |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0502 mL | 15.2509 mL | 30.5018 mL | 61.0035 mL |
| 5mM | 0.6100 mL | 3.0502 mL | 6.1004 mL | 12.2007 mL |
| 10mM | 0.3050 mL | 1.5251 mL | 3.0502 mL | 6.1004 mL |
| 20mM | 0.1525 mL | 0.7625 mL | 1.5251 mL | 3.0502 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.