Forskolin (Coleonol; Colforsin)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$250	Check With Us
500mg	$450	Check With Us
1g	$675	Check With Us

: [email protected] [email protected]

Cat #: V1481 CAS #: 66575-29-9 Purity ≥ 98%

Description: Forskolin (HL-362; L-75-1362B; NSC-357088; NSC-375489; Coleonol; Colforsin), a naturally occurring and cell-permeable diterpene extracted from the Indian Coleus plant (C. forskohlii), is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types.

References: Li X, et al. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015;17(2):195-203.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	410.5
Molecular Formula	C22H34O7
CAS No.	66575-29-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 82 mg/mL (199.8 mM)r
	Water: <1 mg/mLr
	Ethanol: 37 mg/mL (90.1 mM)
Synonyms	Coleonol; HL-362; L-75-1362B; NSC-357088; NSC-375489; HL 362; L 75-1362B; NSC 357088; NSC 375489

Protocol	In Vitro	Forskolin (GMP) (10 μM, 21 days) transdifferentiates mouse fibroblasts to neurons, determined by increased number of TAUEGFP-/TUJ1-positive neuronal cells induced by Ascl1

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4361 mL	12.1803 mL	24.3605 mL	48.7211 mL
5mM	0.4872 mL	2.4361 mL	4.8721 mL	9.7442 mL
10mM	0.2436 mL	1.2180 mL	2.4361 mL	4.8721 mL
20mM	0.1218 mL	0.6090 mL	1.2180 mL	2.4361 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.