ESI-05 (also known as NSC 116966) is a novel, potent and specific antagonist of EPAC2 (exchange protein directly activated by cAMP 2), with an IC50 of 0.4 µM.

PACAP 6-38 is a novel and potent PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM.

HJC0197 (HJC-0197) is a novel and potent EPAC (erythromycin propionate-N-acetylcysteinate) inhibitor and an Epac2 antagonist (IC50=5.9 μM for Epac2) with anticancer activity.

HJC0350 is a potent and selective antagonist/inhibitor of EPAC2 with IC50 of 0.3 μM, it exhibited no inhibition on Epac1.

PACAP 1-27 (HSDGIFTDSYSRYRKQMAVKKYLAAVL), the N-terminal fragment of PACAP-38, is a pituitary adenylate cyclase activating polypeptide that acts as a potent PACAP receptor antagonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively.

PACAP 1-38 is a highly potent agonist of the PACAP (Pituitary adenylate cyclase-activating polypeptide) receptor with Kd of 100 pM.

ST034307 is a novel selective inhibitor of type 1 adenylyl cyclase activity with analgesic properties.

Forskolin (HL-362; L-75-1362B; NSC-357088; NSC-375489; Coleonol; Colforsin), a naturally occurring and cell-permeable diterpene extracted from the Indian Coleus plant (C. forskohlii), is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types.