Flupirtine maleate (D 9998)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$249	Check With Us
1g	$400	Check With Us
5g	$1080	Check With Us

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Cat #: V1475 CAS #: 75507-68-5 Purity ≥ 98%

Description: Flupirtine maleate (W2964; W-2964M; D9998; W-2964; D-9998; Katadolon), the maleate salt form of Flupirtine, is a centrally acting non-opioid analgesic agent and a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

References: Hanna M Jaeger, et al. The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis. Oncotarget. 2015 Jun 10;6(16):14033-44.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	420.39
Molecular Formula	C15H17FN4O2·C4H4O4
CAS No.	75507-68-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 84 mg/mL (199.8 mM)r
	Water: <1 mg/mLr
	Ethanol: 2 mg/mL (4.8 mM)
Solubility In Vivo	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms	W-2964M; W-2964; W2964M; W2964; W 2964M; W 2964; D-9998; Katadolon.

Protocol	In Vitro	Flupirtine (5 and 10 mg/kg) induces acute neuroprotection, reduces motor coordination impairment and ameliorates recombinant tissue plasminogen activator (rtPA)-induced toxicity
	Animal model	Male C57BL6 mice (22-25 g each)
	Dosages	1, 5, 10 mg/kg
	Administration	Single intraperitoneal injection during post-ischemic reperfusion

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3787 mL	11.8937 mL	23.7874 mL	47.5749 mL
5mM	0.4757 mL	2.3787 mL	4.7575 mL	9.5150 mL
10mM	0.2379 mL	1.1894 mL	2.3787 mL	4.7575 mL
20mM	0.1189 mL	0.5947 mL	1.1894 mL	2.3787 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.