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Flufenamic acid (CI-440; CN-27554)

This product is for research use only, not for human use. We do not sell to patients.

Flufenamic acid (CI-440; CN-27554)
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Cat #: V1968 CAS #: 530-78-9 Purity ≥ 98%

Description: Flufenamic Acid (CI-440; CN-27554) is an anti-inflammatory agent of the NSAIDs (non-steroidal anti-inflammatory agent) class.

References: Guinamard R, et al. Flufenamic acid as an ion channel modulator. Pharmacol Ther. 2013 May;138(2):272-84.

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Molecular Weight (MW)281.23
Molecular FormulaC14H10F3NO2
CAS No.530-78-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 56 mg/mL (199.1 mM)r
Water: <1 mg/mLr
Ethanol: 56 mg/mL (199.1 mM)
SMILES CodeO=C(O)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2
SynonymsCI-440; CN-27554; INF-1837; CI 440; CN 27554; INF 1837; CI440; CN27554; INF1837
ProtocolIn VitroFlufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid inhibits a wide spectrum of TRP channels, including: C3, C7, M2, M3, M4, M5, M7, M8, V1, V3, and V4 but activates at least two TRP channels (C6 and A1).
In VivoFlufenamic acid (50 mg/kg, i.p.) has anti-inflammatory effect in a mouse model of Vibrio cholerae El Tor variant (EL)-induced diarrhea and significantly abrogates EL-induced intestinal fluid secretion and barrier disruption at 20 mg/kg. Furthermore, Flufenamic acid suppresses NF-κB nuclear translocation and expression of proinflammatory mediators and promotes AMPK phosphorylation in the EL-infected mouse intestine.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.5558 mL17.7790 mL35.5581 mL71.1162 mL
5mM0.7112 mL3.5558 mL7.1116 mL14.2232 mL
10mM0.3556 mL1.7779 mL3.5558 mL7.1116 mL
20mM0.1778 mL0.8890 mL1.7779 mL3.5558 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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V1
 
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Concentration(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.