Flibanserin | CAS 167933-07-5

Flibanserin

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$450	Check With Us
500mg	$750	Check With Us
1g	$1130	Check With Us

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Cat #: V8491 CAS #: 167933-07-5 Purity ≥ 99%

Description: Flibanserin (BIMT-17; BIMT-17BS; EBD-6396; Girosa; trade name Addyi) is a novel and potent agonist of the 5-HT1A and serotonergic antidepressant approved for the treatment of pre-menopausal women with hypoactive sexual desire disorder (HSDD).

References: Fayed M, et al. Insights into Flibanserin Oxidative Stress Degradation Pathway: In Silico – In Vitro Toxicity Assessment of Its Degradates[J]. New Journal of Chemistry, 2021.

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Molecular Weight (MW)	390.40
Molecular Formula	C20H21F3N4O
CAS No.	167933-07-5

Protocol	In Vitro	Flibanserin (0.01-100 μM; 72 h) can transform into two degradation products DP1 and DP2 with no toxicity potential after oxidative degradation
	In Vivo	Flibanserin (1, 10, 30 mg/kg; i.p.; single dose) shows different pharmacological properties in prefrontal cortex, hippocampus and midbrain. The 5-HT1A receptor occupancy in cortex indicates it’s the more sensitive than other brain region
	Animal model	Long Evans female rats (225-250 g)
	Dosages	15 mg/kg; 45 mg/kg
	Administration	Oral gavage; twice a day for 22 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5615 mL	12.8074 mL	25.6148 mL	51.2295 mL
5mM	0.5123 mL	2.5615 mL	5.1230 mL	10.2459 mL
10mM	0.2561 mL	1.2807 mL	2.5615 mL	5.1230 mL
20mM	0.1281 mL	0.6404 mL	1.2807 mL	2.5615 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.