Filibuvir
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1050 | To Be Confirmed |
| 100mg | $1850 | To Be Confirmed |
| 200mg | $2775 | To Be Confirmed |
: Cat #: V21027 CAS #: 877130-28-4 Purity ≥ 99%
Description: Filibuvir (PF00868554; PF-00868554) is a novel and potent NS5B inhibitor of the non-nucleoside inhibitor (NNI) class developed for the treatment of hepatitis C.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 503.64 |
|---|---|
| Molecular Formula | C29H37N5O3 |
| CAS No. | 877130-28-4 |
| Protocol | In Vitro | Filibuvir (0.01-10000 nM; 48 h) inhibits the WT 1b replicon in a dose-dependent manner, with an EC50 of ∼70 nM in Huh7.5 cells harboring the HCV replicon. Filibuvir binds to the HCV polymerase with a dissociation constant of 29 nM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9855 mL | 9.9277 mL | 19.8555 mL | 39.7109 mL |
| 5mM | 0.3971 mL | 1.9855 mL | 3.9711 mL | 7.9422 mL |
| 10mM | 0.1986 mL | 0.9928 mL | 1.9855 mL | 3.9711 mL |
| 20mM | 0.0993 mL | 0.4964 mL | 0.9928 mL | 1.9855 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.