Fexinidazole

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$500	Check With Us
200mg	$750	Check With Us
500mg	$1135	Check With Us

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Cat #: V12088 CAS #: 59729-37-2 Purity ≥ 99%

Description: Fexinidazole (Hoe239; Hoe-239) is a novel, potent and nitroimidazole-based antiparasitic agent that has been approved in 2021 by FDA as the first all-oral medication to treat African trypanosomiasis caused by Trypanosoma brucei gambiense.

References: Kaiser M, et al. Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness. Antimicrob Agents Chemother. 2011 Dec;55(12):5602-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	279.31
Molecular Formula	C12H13N3O3S
CAS No.	59729-37-2

Protocol	In Vitro	Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested
	In Vivo	Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities[
	Animal model	Adult female NMRI mice weighing between 20 and 25 g T. b. rhodesiense[1]
	Dosages	20, 50 mg/kg (IP) or 25, 50, 100 mg/kg (PO)
	Administration	IP or PO; daily; four consecutive days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.5803 mL	17.9013 mL	35.8025 mL	71.6050 mL
5mM	0.7161 mL	3.5803 mL	7.1605 mL	14.3210 mL
10mM	0.3580 mL	1.7901 mL	3.5803 mL	7.1605 mL
20mM	0.1790 mL	0.8951 mL	1.7901 mL	3.5803 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.