Etifoxine (HOE36801)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$450	Check With Us
250mg	$850	Check With Us
500mg	$1275	Check With Us

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Cat #: V31591 CAS #: 21715-46-8 Purity ≥ 99%

Description: Etifoxine (HOE-36801) and etafenoxine, is a non-benzodiazepine GABAergic anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s, and sold in approximately 40 countries for anxiety disorders, without the sedation and ataxia associated with benzodiazepine drugs.

References: Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA(A) receptors in rodents. Neurosci Res. 2002 Oct;44(2):167-72.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	300.78
Molecular Formula	C₁₇H₁₇ClN₂O
CAS No.	21715-46-8
SMILES Code	ClC1=CC=C2C(C(C3=CC=CC=C3)(C)OC(NCC)=N2)=C1.

Protocol	In Vitro	Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX
	In Vivo	Etifoxine competitively inhibits [35S]TBPS binding with micromolar potency in rat brain
	Animal model	Six-week old BALB/cByJ and C57BL/6J mice (20-25 g)
	Dosages	3.125-50 mg/kg.
	Administration	Intraperitoneal injection.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.3247 mL	16.6234 mL	33.2469 mL	66.4938 mL
5mM	0.6649 mL	3.3247 mL	6.6494 mL	13.2988 mL
10mM	0.3325 mL	1.6623 mL	3.3247 mL	6.6494 mL
20mM	0.1662 mL	0.8312 mL	1.6623 mL	3.3247 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.