Home > Signaling Pathways>NF-kB>NF-κB>Ethacrynic acid
Ethacrynic acid

This product is for research use only, not for human use. We do not sell to patients.

Ethacrynic acid
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
25g$650Check With Us
50g$1050Check With Us
100g$1575Check With Us

Cat #: V8949 CAS #: 58-54-8 Purity ≥ 99%

Description: Ethacrynic acid (MK-595; NSC-624008; NSC-85791; Hydromedin; Crinuryl; Mingit; Etacrinic acid; Otacril Reomax; Taladren; Edecrin) is a high ceiling loop diuretic acting as a Na+/K+/2Cl- cotransporter NKCC2 inhibitor.

References: Li XQ, et al. Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation. Drug Metab Dispos. 2019 Nov;47(11):1247-1256.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)303.14
Molecular FormulaC13H12Cl2O4
CAS No.58-54-8
SMILES CodeCCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
SynonymsMK-595; NSC-624008; NSC-85791; Hydromedin; Crinuryl; Mingit; Etacrinic acid; Otacril Reomax; Taladren; Edecrin
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.2988 mL16.4940 mL32.9881 mL65.9761 mL
5mM0.6598 mL3.2988 mL6.5976 mL13.1952 mL
10mM0.3299 mL1.6494 mL3.2988 mL6.5976 mL
20mM0.1649 mL0.8247 mL1.6494 mL3.2988 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.