EST64454 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1200 | Check With Us |
| 250mg | $1850 | Check With Us |
| 500mg | $2776 | Check With Us |
: Cat #: V2275 CAS #: 1950569-11-5 Purity ≥ 99%
Description: EST64454 HCl is a potent ,selective and orally active sigma-1 receptor antagonist( Ki = 22 nM).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
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| Molecular Weight (MW) | 400.8548 |
|---|---|
| Molecular Formula | C18H23ClF2N4O2 |
| CAS No. | 1950569-11-5 |
| Synonyms | EST64454 hydrochloride; EST-64454; EST64454; EST 64454; |
| Protocol | In Vivo | EST64454 (10 mg/kg; p.o.; male Wistar rats) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% are 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively |
|---|---|---|
| Animal model | Male Wistar rats (250-300 g) | |
| Dosages | 10 mg/kg | |
| Administration | P.o. (Pharmacokinetic Analysis) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4947 mL | 12.4733 mL | 24.9467 mL | 49.8934 mL |
| 5mM | 0.4989 mL | 2.4947 mL | 4.9893 mL | 9.9787 mL |
| 10mM | 0.2495 mL | 1.2473 mL | 2.4947 mL | 4.9893 mL |
| 20mM | 0.1247 mL | 0.6237 mL | 1.2473 mL | 2.4947 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.