Esmolol HCl | CAS 81161-17-3

Esmolol HCl

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Size	Price	Stock
2g	$590	Check With Us
5g	$950	Check With Us
10g	$1425	Check With Us

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Cat #: V1154 CAS #: 81161-17-3 Purity ≥ 98%

Description: Esmolol HCl (Brevibloc; ASL-8052; ASL 8052), the hydrochloride salt of esmolol, is a potent and cardioselective beta-blocker used to control rapid heartbeats or abnormal heart rhythms.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	331.83
Molecular Formula	C16H25NO4.HCl
CAS No.	81161-17-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 66 mg/mL (198.9 mM)r
	Water: 66 mg/mL (198.9 mM)r
	Ethanol: 66 mg/mL (198.9 mM)
Synonyms	ASL-8052; Esmolol Hydrochloride; Esmolol HCL; Brevibloc; ASL-8052; Asl 8052; ASL 8052; ASL8052; ASL 8052; Brevibloc; esmolol; esmolol hydrochloride

Protocol	In Vitro	Esmolol hydrochloride is the hydrochloride salt form of Esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, Esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0136 mL	15.0680 mL	30.1359 mL	60.2718 mL
5mM	0.6027 mL	3.0136 mL	6.0272 mL	12.0544 mL
10mM	0.3014 mL	1.5068 mL	3.0136 mL	6.0272 mL
20mM	0.1507 mL	0.7534 mL	1.5068 mL	3.0136 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.