Escitalopram Oxalate (Citalopram oxalate)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$490	Check With Us
5g	$750	Check With Us
10g	$1125	Check With Us

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Cat #: V1030 CAS #: 219861-08-2 Purity ≥ 98%

Description: Escitalopram Oxalate (Cipralex; Lexapro; Lu10171; Lu-10171; Citalopram;Cytalopram), the oxalate salt of Escitalopram which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) with a Ki of 0.89 nM.

References: Wu C , et al. Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity. Neurobiol Aging. 2018;67:137-147.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	414.43
Molecular Formula	C20H21FN2O.C2H2O4
CAS No.	219861-08-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 83 mg/mL (200.3 mM)r
	Water: 25 mg/mL (60.3 mM)r
	Ethanol: <1 mg/mL
Synonyms	Lu-10-171; Escitalopram Oxalate; Cipralex; Lexapro; (S)-Citalopram Oxalate; Lu10171; Lu 10171; UNII-5U85DBW7LO; Citalopram;Cytalopram; Escitalopram Lexapro

Protocol	In Vivo	Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats
	Animal model	Male Sprague-Dawley rats
	Dosages	10 mg/kg
	Administration	I.p.; daily for 28 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4130 mL	12.0648 mL	24.1295 mL	48.2591 mL
5mM	0.4826 mL	2.4130 mL	4.8259 mL	9.6518 mL
10mM	0.2413 mL	1.2065 mL	2.4130 mL	4.8259 mL
20mM	0.1206 mL	0.6032 mL	1.2065 mL	2.4130 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.