Epacadostat (INCB024360)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $650 | In Stock |
| 1g | $950 | In Stock |
| 5g | $2405 | In Stock |
: Cat #: V0942 CAS #: 1204669-58-8 Purity ≥ 98%
Description: Epacadostat (formerly INCB024360; IDO-IN-1; INCB-024360; INCB-24360; INCB24360) is an orally bioavailable, potent and selective IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with potential immunomodulating and antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 438.23 |
|---|---|
| Molecular Formula | C11H13BrFN7O4S |
| CAS No. | 1204669-58-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 87 mg/mL (198.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 53 mg/mL (120.9 mM) | |
| Solubility In Vivo | 10%DMSO+90%PEG400: 30mg/mL |
| SMILES Code | O=S(NCCNC1=NON=C1/C(NC2=CC=C(F)C(Br)=C2)=N/O)(N)=O |
| Synonyms | INCB14943-analog; INCB-14943-analog; INCB 14943-analog; INCB024360 or INCB24360; Epacadostat-analog; IDO-IN-1; INCB 024360; INCB-024360; INCB-24360; INCB 24360; |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2819 mL | 11.4095 mL | 22.8191 mL | 45.6381 mL |
| 5mM | 0.4564 mL | 2.2819 mL | 4.5638 mL | 9.1276 mL |
| 10mM | 0.2282 mL | 1.1410 mL | 2.2819 mL | 4.5638 mL |
| 20mM | 0.1141 mL | 0.5705 mL | 1.1410 mL | 2.2819 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.