Enzalutamide carboxylic acid

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Enzalutamide carboxylic acid
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500mg$2280Check With Us

Cat #: V40125 CAS #: 1242137-15-0 Purity ≥ 99%

Description: Enzalutamide carboxylic acid (also called MDV-3100 carboxylic acid) is a major inactive metabolite of Enzalutamide (MDV3100; Xtandi) which is a non-steroidal androgen-receptor (AR) antagonist approved for use as an anticancer drug.

References: van Nuland M, et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.

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Molecular Weight (MW)451.39
Molecular FormulaC20H13F4N3O3S
CAS No.1242137-15-0
SynonymsEnzalutamide carboxylic acid; MDV3100 carboxylic acid; MDV-3100 carboxylic acid
ProtocolIn VitroEnzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2154 mL11.0769 mL22.1538 mL44.3076 mL
5mM0.4431 mL2.2154 mL4.4308 mL8.8615 mL
10mM0.2215 mL1.1077 mL2.2154 mL4.4308 mL
20mM0.1108 mL0.5538 mL1.1077 mL2.2154 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.