2R,4S-Sacubitril is an impurity of Sacubitril (AHU-377; AHU377), which is an FDA approved medication used in combination with valsartan (trade name Entrosto for the combo/cocktail)for the treatment of heart failure.

16alpha-Hydroxyprednisolone (Budesonide Impurity A) is a CYP3A-mediated metabolite and 22(R) epimer of budesonide which is a glucocorticoid.

Rezivertinib analogue 1 is a Osimertinib Impurity.

ent-Ezetimibe is the RRS-enantiomer and impurity of Ezetimibe (SCH-58235), which is a selective inhibitor of cholesterol absorption in the gut used to lower cholesterol levels.

Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.

GS-704277 is a phase II alanine conjugated metabolite of Remdesivir.

Enzalutamide carboxylic acid (also called MDV-3100 carboxylic acid) is a major inactive metabolite of Enzalutamide (MDV3100; Xtandi) which is a non-steroidal androgen-receptor (AR) antagonist approved for use as an anticancer drug.

4-Desmethyl Istradefylline is the demethylated metabolite of Istradefylline （KW-6002; Nourianz), which is an orally bioavailable adenosine A2A receptor (A2AR) antagonist approved for the treatment of PD (Parkinson’s disease).

Atorvastatin Epoxy Tetrahydrofuran Impurity is an oxidative degradation product of Atorvastatin, which is an anti-hyperlipidemic drug and selective inhibitor of HMG-CoA reductase.

Dihydro Dutasteride is an impurity generated during the production of Dutasteride (GI198745, GG745; GI-198745, GG-745; Avodart, Avidart), which is an approved anticancer medication and a 5-α reductase inhibitor.