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Emtricitabine S-oxide (Emtricitabine sulfoxide)

This product is for research use only, not for human use. We do not sell to patients.

Emtricitabine S-oxide (Emtricitabine sulfoxide)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$5850To Be Confirmed
200mg$8775To Be Confirmed
500mg$14800To Be Confirmed
email: [email protected]        [email protected]

Cat #: V32666 CAS #: 152128-77-3 Purity ≥ 99%

Description: Emtricitabine S-oxide (also called Emtricitabine Degradant-III; Emtricitabine sulfoxide) is a degradation product (S-oxidized impurity) of Emtricitabine (BW-1592; FTC; BW1592; Emtriva; Coviracil; Racivir), which is a potent nucleoside reverse transcriptase inhibitor (NRTI) that has been approved for the treatment of both human immunodeficiency virus (HIV) and hepatitis B virus.

References: A Prakash, et al. Forced degradation study of emtricitabine for evaluation of genotoxic impurity in active pharmaceutical ingredient's (API) shelf life. World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(7), 1909-1919.

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Molecular Weight (MW)263.25
Molecular FormulaC8H10FN3O4S
CAS No.152128-77-3
SynonymsEmtricitabine Degradant-III; Emtricitabine sulfoxide; Emtricitabine S-oxide;
ProtocolIn VitroEmtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III).
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.7987 mL18.9934 mL37.9867 mL75.9734 mL
5mM0.7597 mL3.7987 mL7.5973 mL15.1947 mL
10mM0.3799 mL1.8993 mL3.7987 mL7.5973 mL
20mM0.1899 mL0.9497 mL1.8993 mL3.7987 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Volume(start)
V1
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.