Dronedarone (SR33589)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$750	Check With Us
10g	$1250	Check With Us
20g	$1875	Check With Us

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Cat #: V20254 CAS #: 141626-36-0 Purity ≥ 99%

Description: Dronedarone (formerly SR-33589; D-03914; S-7529; D-4689; W-3083; RL-01735; Multaq) is a non-iodinated amiodarone analog and a Class III antiarrhythmic as well as multi channel blocker approved for the treatment for Atrial fibrillation (AF).

References: Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna). 2019 Feb;126(2):115-122.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	556.76
Molecular Formula	C31H44N2O5S
CAS No.	141626-36-0
Synonyms	SR 33589; SR33589; D03914; S7529; D4689; W3083; RL01735; D-03914; S-7529; D-4689; W-3083; RL-01735

Protocol	In Vivo	Dronedarone (intraperitoneal injection; 25-100 mg/kg) exhibits anticonvulsant effects in a dose-dependent manner and increases the threshold for electroconvulsions in mice
	Animal model	Tonic-clonic seizures in male albino Swiss outbred mice
	Dosages	25 mg/kg; 50 mg/kg; 75 mg/kg; 100 mg/kg
	Administration	Intraperitoneal injection

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7961 mL	8.9805 mL	17.9611 mL	35.9221 mL
5mM	0.3592 mL	1.7961 mL	3.5922 mL	7.1844 mL
10mM	0.1796 mL	0.8981 mL	1.7961 mL	3.5922 mL
20mM	0.0898 mL	0.4490 mL	0.8981 mL	1.7961 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.