Dronedarone HCl (SR33589)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $249 | Check With Us |
| 1g | $390 | Check With Us |
| 5g | $1055 | Check With Us |
: Cat #: V1670 CAS #: 141625-93-6 Purity ≥ 98%
Description: Dronedarone HCl (formerly SR-33589; D4689; W3083; D03914; S-7529; RL01735), the hydrochloride salt of dronedarone, is a non-iodinated amiodarone analog approved for the treatment for Atrial fibrillation (AF).
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| Molecular Weight (MW) | 593.22 |
|---|---|
| Molecular Formula | C31H44N2O5S.HCl |
| CAS No. | 141625-93-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 80 mg/mL (134.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 40 mg/mL (67.4 mM) | |
| Synonyms | SR 33589; SR33589; Dronedarone Hydrochloride; 4CH-007232; SR-33589; D4689; W3083; D03914; S-7529; MCULE-2160502046; RL01735; RTC-070901; AK-72887; BC201083; BR-72887; HY-75839; KB-76727; AB2000517; ST2413542; Dronedarone HCl; UNII-FA36DV299Q |
| Protocol | In Vitro | Dronedarone (SR-33589) is a multichannel blocker for atrial fibrillation . It is a potent inhibitor of the acetylcholine-activated K+ current from atrial and sinoatrial nodal tissue, and inhibits the rapid delayed rectifier more potently than slow and inward rectifier K+ currents and inhibits L-type calcium current. Under whole-cell patch clamp, it blocks IKr (IC50=3 μM) and ICa-L (IC50=0.18 μM). The effects on ICa-L are use- and frequency-dependent. Dronedarone inhibits current carried by human ether-a-go-go gene (HERG)-expressing oocytes (analagous to IKr) with an IC50 of 9 μM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6857 mL | 8.4286 mL | 16.8572 mL | 33.7143 mL |
| 5mM | 0.3371 mL | 1.6857 mL | 3.3714 mL | 6.7429 mL |
| 10mM | 0.1686 mL | 0.8429 mL | 1.6857 mL | 3.3714 mL |
| 20mM | 0.0843 mL | 0.4214 mL | 0.8429 mL | 1.6857 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.