Dorsomorphin (BML275)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$1360	Check With Us
1g	$2050	Check With Us
5g	$5190	Check With Us

: [email protected] [email protected]

Cat #: V0251 CAS #: 866405-64-3 Purity ≥ 98%

Description: Dorsomorphin (BML-275) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor with a Ki of 109 nM in cell-free assays, exhibiting little effects against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3.

References: Zhou G, et al. Role of AMP-activated protein kinase in mechanism of action. J Clin Invest. 2001 Oct;108(8):1167-74.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	399.49
Molecular Formula	C24H25N5O
CAS No.	866405-64-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 3 mg/mL (7.5 mM)r
	Water: <1 mg/mLr
	Ethanol: 2 mg/mL (5.0 mM)
SMILES Code	C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2
Synonyms	BML-275,Compound C; Dorsomor; BML275; BML-275; BML 275; CpdC;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5032 mL	12.5160 mL	25.0319 mL	50.0638 mL
5mM	0.5006 mL	2.5032 mL	5.0064 mL	10.0128 mL
10mM	0.2503 mL	1.2516 mL	2.5032 mL	5.0064 mL
20mM	0.1252 mL	0.6258 mL	1.2516 mL	2.5032 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.