Marein is a novel and potent hypoglycemic drug.

Ginkgolide C (BN-52022) is a naturally occuring product isolated from Ginko and a GABA-A receptor, α-1 GlyR, and PAF receptor antagonist.

BC-1618 is a potent and orally active Fbxo48 inhibitor.

IM156 (also known as HL-156A) is a metformin derivative thac acts as a novel and highly potent AMPK activator that increases AMPK phosphorylation.

ASP4132 tosylate (ASP-4132) is an oral bioavailable AMPK activator (EC50 = 18 nM) with potential anticancer activity.

Buformin hydrochloride (NSC-528218; NSC528218; 1-butylbiguanide) is an orally available AMPK activator used as an antidiabetic drug belonging to the biguanide class.

MK-8722 (MK8722) is a novel, potent allosteric pan-AMPK activator with anti-diabetic effects.

Acadesine (also known as NSC105823, AICA-riboside, and AICAR) is a novel and potent AMPK (AMP-activated protein kinase) activator with potential antitumor and antidiabetic activity.

Buformin (NSC-528218; 1-butylbiguanide) is an orally bioavailable AMPK activator approved for use as an antidiabetic drug.

O-304 is a first-in-class, orally bioavailable pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK.