Dorsomorphin 2HCl (BML275)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$1150	Check With Us
1g	$1750	Check With Us
5g	$4430	Check With Us

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Cat #: V0246 CAS #: 1219168-18-9 Purity ≥ 98%

Description: Dorsomorphin 2HCl (formerly BML-275 dihydrochloride) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor that inhibits AMPK with a Ki of 109 nM in cell-free assays, exhibiting little inhibition against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3.

References: Zhou G, et al. Role of AMP-activated protein kinase in mechanism of action. J Clin Invest. 2001 Oct;108(8):1167-74.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	472.41
Molecular Formula	C24H27Cl2N5O
CAS No.	1219168-18-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO:94 mg/mL (199 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	PBS: 15 mg/mL
SMILES Code	[H]Cl.[H]Cl.C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2
Synonyms	Compound C; BML275; BML 275; BML-275; CpdC

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1168 mL	10.5840 mL	21.1681 mL	42.3361 mL
5mM	0.4234 mL	2.1168 mL	4.2336 mL	8.4672 mL
10mM	0.2117 mL	1.0584 mL	2.1168 mL	4.2336 mL
20mM	0.1058 mL	0.5292 mL	1.0584 mL	2.1168 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.