DORA-22 | CAS 1088991-95-0

DORA-22

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Cat #: V3228 CAS #: 1088991-95-0 Purity ≥ 98%

Description: DORA-22 is a novel, potent and selective dual orexin receptor antagonist that may be useful for insomnia and AD-relevant symptoms. It can lower histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine. DORA-22 suppresses the release of the wake neurotransmitter histamine in the lateral hypothalamus, prefrontal cortex, and hippocampus with no significant alterations in acetylcholine levels. Compared with the GABAA modulator eszopiclone, DORA-22 elicits a neurotransmitter profile consistent with wake reduction that does not impinge on neurotransmitter levels associated with cognition and rapid eye movement sleep. DORAs may improve sleep in AD patients. Further investigations should optimize the dose and duration of DORA-22 treatment and explore additional AD-relevant animal models and cognitive tests.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	424.45
Molecular Formula	C23H22F2N4O2
CAS No.	1088991-95-0
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
SMILES Code	N/A
Synonyms	DORA 22; DORA-22; DORA22

Related Biological Data

Comparison of sleep percent before and after chronic treatment with DORA-22 (100 mg/kg per day for 5 weeks). Alzheimers Dement (N Y). 2019 Feb 28;5:70-80.

Effects of sex and chronic DORA-22 treatment (100 mg/kg per day for 5 weeks) on sleep percent in WT and 5XFAD mice.

Cortical gene expression of neuroinflammatory markers in 5XFAD mice treated with DORA-22(100 mg/kg per day for 5 weeks). Gene expression analysis was conducted using custom TaqMan Microfluidic Arrays on RNA isolated from neocortical tissue. The inflammatory markers chosen were selected to represent five discrete classes of neuroinflammatory responses based on the presumed function of the markers. The categories included (A) complement system, (B) cytokines, (C) chemokines, (D) reactive microglia markers, and (E) reactive astrocyte markers. Alzheimers Dement (N Y). 2019 Feb 28;5:70-80.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3560 mL	11.7800 mL	23.5599 mL	47.1198 mL
5mM	0.4712 mL	2.3560 mL	4.7120 mL	9.4240 mL
10mM	0.2356 mL	1.1780 mL	2.3560 mL	4.7120 mL
20mM	0.1178 mL	0.5890 mL	1.1780 mL	2.3560 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.