Dolutegravir intermediate-1

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100g	$400	Check With Us
200g	$650	Check With Us
500g	$1100	Check With Us

: [email protected] [email protected]

Cat #: V33193 CAS #: 1335210-23-5 Purity ≥ 99%

Description: Dolutegravir intermediate-1 is an intermediate to the synthesis of dolutegravir which is an HIV integrase inhibitor for the treatment of human immunodeficiency virus (HIV)-l infection.

References: Sivaram Prasad, et al. Process for the preparation of dolutegravir . WO 2016125192 A2.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	315.28
Molecular Formula	C13H17NO8
CAS No.	1335210-23-5
Synonyms	Dolutegravir intermediate-

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1718 mL	15.8589 mL	31.7178 mL	63.4357 mL
5mM	0.6344 mL	3.1718 mL	6.3436 mL	12.6871 mL
10mM	0.3172 mL	1.5859 mL	3.1718 mL	6.3436 mL
20mM	0.1586 mL	0.7929 mL	1.5859 mL	3.1718 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.