Dienogest (STS-557)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | Check With Us |
| 1g | $750 | Check With Us |
| 5g | $2025 | Check With Us |
: Cat #: V1727 CAS #: 65928-58-7 Purity ≥ 98%
Description: Dienogest (formerly BAY86-5258; M-18575; MJR-35; ZK-37659; STS-557; Dinagest; Endometrion; Visanne) is a synthetic and orally bioavailable progesterone that was approved for use in contraception and the treatment of endometriosis.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 311.42 |
|---|---|
| Molecular Formula | C20H25NO2 |
| CAS No. | 65928-58-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 62 mg/mL (199.1 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | STS-557; STS 557; STS557; BAY86-5258; BAY 86-5258; BAY-86-5258; Dinagest; Endometrion; M 18575; MJR-35; Visanne; ZK 37659. |
| Protocol | In Vivo | Dienogest (1 mg/kg； Oral administration once daily for 14 days) Modulating angiogenesis of ectopic endometrial lesions in a rat endometrial autograft model |
|---|---|---|
| Animal model | Female Wistar rats (8 to 10-week-old; 180-220 g; rat endometrial autograft model) | |
| Dosages | 1 mg/kg | |
| Administration | Oral administration; once daily for 14 days. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2111 mL | 16.0555 mL | 32.1110 mL | 64.2220 mL |
| 5mM | 0.6422 mL | 3.2111 mL | 6.4222 mL | 12.8444 mL |
| 10mM | 0.3211 mL | 1.6055 mL | 3.2111 mL | 6.4222 mL |
| 20mM | 0.1606 mL | 0.8028 mL | 1.6055 mL | 3.2111 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.