Diclofenac Sodium (GP 45840)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100g	$550	Check With Us
200g	$850	Check With Us
500g	$1280	Check With Us

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Cat #: V1051 CAS #: 15307-79-6 Purity ≥ 98%

Description: Diclofenac Sodium (Abitren, Blesin, Delimon, Allvoran, Berifen, Delphimix, Voltaren, Voltarol; Assaren, Batafil, GP-45840) is a nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with potential anti-inflammatory activity.

References: Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	318.13
Molecular Formula	C14H10Cl2NNaO2
CAS No.	15307-79-6
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 64 mg/mL (201.2 mM)rr
	Water: 14 mg/mL (44.0 mM)rr
	Ethanol: 64 mg/mL (201.2 mM)
SMILES Code	c1ccc(c(c1)CC(=O)[O-])Nc2c(cccc2Cl)Cl.[Na+]
Synonyms	GP-45840; Abitren, Voltaren, Voltaren-XR, Allvoran, Delimon, Neriodin, Orthophen, Sodium diclofenac, Voltarene, Voltarol; GP45840; GP 45840; Assaren, Batafil, Berifen, Delphimix, Diclofenac sodium, Blesin

Protocol	In Vitro	Diclofenac potently blocks COX-1-mediated production of prostaglandins, IC by U937 cell microsomes50 is 7±3 nM

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1434 mL	15.7168 mL	31.4337 mL	62.8674 mL
5mM	0.6287 mL	3.1434 mL	6.2867 mL	12.5735 mL
10mM	0.3143 mL	1.5717 mL	3.1434 mL	6.2867 mL
20mM	0.1572 mL	0.7858 mL	1.5717 mL	3.1434 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.