Dexmedetomidine HCl [(S)-Medetomidine]
This product is for research use only, not for human use. We do not sell to patients.
![Dexmedetomidine HCl [(S)-Medetomidine]](https://invivochem.net/wp-content/uploads/2023/05/CgAGS12cQXeAdbqgAAAJBqr1_Xs096.gif "Dexmedetomidine HCl [(S)-Medetomidine]")
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| Size | Price | Stock |
|---|---|---|
| 500mg | $630 | Check With Us |
| 1g | $930 | Check With Us |
| 5g | $2420 | Check With Us |
: Cat #: V1143 CAS #: 145108-58-3 Purity ≥ 98%
Description: Dexmedetomidine HCl (Precedex), the hydrochloride salt of Dexmedetomidine which is the dexter isomer of medetomidine, is a highly selective and potent alpha-2 adrenoceptor agonist with sedative effects.
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| Molecular Weight (MW) | 236.74 |
|---|---|
| Molecular Formula | C13H16N2.HCl |
| CAS No. | 145108-58-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 40 mg/mL (199.7 mM)r |
| Water: 40 mg/mL (199.7 mM)r | |
| Ethanol: 40 mg/mL (199.7 mM) | |
| Synonyms | Dexmedetomidine HCl; Dexmedetomidine Hydrochloride; Precedex; |
| Protocol | In Vitro | Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine |
|---|---|---|
| In Vivo | Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats | |
| Animal model | Female Sprague-Dawley rats (270-350 g) | |
| Dosages | 1, 5, 10, 50, 100 mg/kg | |
| Administration | I.v. at 5-min intervals |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.2240 mL | 21.1202 mL | 42.2404 mL | 84.4809 mL |
| 5mM | 0.8448 mL | 4.2240 mL | 8.4481 mL | 16.8962 mL |
| 10mM | 0.4224 mL | 2.1120 mL | 4.2240 mL | 8.4481 mL |
| 20mM | 0.2112 mL | 1.0560 mL | 2.1120 mL | 4.2240 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.