Devimistat (CPI-613)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$400	In Stock
1g	$600	In Stock
5g	$900	In Stock

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Cat #: V0853 CAS #: 95809-78-2 Purity ≥ 98%

Description: Devimistat (formerly also known as CPI613; CPI 613; CPI-613), a synthetic lipoate analog, is a novel and potent inhibitor of pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase with potential chemopreventive and antineoplastic activities.

References: Sakuratani T, et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway. Virchows Arch. 2021;478(3):401-411.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	388.59
Molecular Formula	C22H28O2S2
CAS No.	95809-78-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 78 mg/mL (200.7 mM)r
	Water: <1 mg/mLr
	Ethanol: 78 mg/mL (200.7 mM)
Solubility In Vivo	1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
SMILES Code	O=C(O)CCCCC(SCC1=CC=CC=C1)CCSCC2=CC=CC=C2
Synonyms	CPI613; CPI-613; Devimistat; CPI 613 Chemical Name: 6,8-bis(benzylthio)octanoic acid

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5734 mL	12.8670 mL	25.7341 mL	51.4681 mL
5mM	0.5147 mL	2.5734 mL	5.1468 mL	10.2936 mL
10mM	0.2573 mL	1.2867 mL	2.5734 mL	5.1468 mL
20mM	0.1287 mL	0.6434 mL	1.2867 mL	2.5734 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.