Detomidine HCl (MPV 253; MPV253)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $699 | Check With Us |
| 1g | $1070 | Check With Us |
| 5g | $2675 | Check With Us |
: Cat #: V1108 CAS #: 90038-01-0 Purity ≥ 98%
Description: Detomidine HCl (MPV 253; MPV-253), the hydrochloride salt of detomidine, is an alpha2/α2-Adrenoreceptor agonist with sedative properties.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 222.71 |
|---|---|
| Molecular Formula | C12H14N2.HCl |
| CAS No. | 90038-01-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 45 mg/mL (202.1 mM)r |
| Water: 45 mg/mL (202.1 mM)r | |
| Ethanol: | |
| Synonyms | MPV 253; MPV253; Detomidine hydrochloride; MPV-253; Detomidine HCl; |
| Protocol | In Vitro | Currently, detomidine is only licenced for use in horses. α2-adrenergic agonists produce dose-dependent analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.4901 mL | 22.4507 mL | 44.9014 mL | 89.8029 mL |
| 5mM | 0.8980 mL | 4.4901 mL | 8.9803 mL | 17.9606 mL |
| 10mM | 0.4490 mL | 2.2451 mL | 4.4901 mL | 8.9803 mL |
| 20mM | 0.2245 mL | 1.1225 mL | 2.2451 mL | 4.4901 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.