Desidustat | CAS 1616690-16-4

Desidustat

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1250	Check With Us
500mg	$1850	Check With Us
1g	$2775	Check With Us

: [email protected] [email protected]

Cat #: V19624 CAS #: 1616690-16-4 Purity ≥ 98%

Description: Desidustat is an antianaemic drug candidate under investigation for the treatment of anemia of chronic kidney disease. It acts as an inhibitor of HIF hydroxylase. Reference: Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation. Eur J Pharmacol. 2019 Jan 15;843:113-120.

References: [1]. Ranjit C, et al. Novel quinolone derivatives. Patent. WO2014102818A1.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	332.312
Molecular Formula	C16H16N2O6
CAS No.	1616690-16-4
SMILES Code	O=C(O)CNC(C1=C(O)C2=C(N(OCC3CC3)C1=O)C=CC=C2)=O
Synonyms	Desidustat

Protocol	In Vivo	Desidustat (oral; 10-100 mg/kg) has good efficacy in vivo.
	Animal model	C57 Mice
	Dosages	10, 30, 50, 100 mg/kg; 20 mg /kg
	Administration	oral gavage; oral, once, daily, for 7 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0092 mL	15.0461 mL	30.0922 mL	60.1844 mL
5mM	0.6018 mL	3.0092 mL	6.0184 mL	12.0369 mL
10mM	0.3009 mL	1.5046 mL	3.0092 mL	6.0184 mL
20mM	0.1505 mL	0.7523 mL	1.5046 mL	3.0092 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.