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Dehydroevodiamine

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Dehydroevodiamine
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Size Price Stock
1g$450Check With Us
2g$750Check With Us
5g$1265Check With Us

Cat #: V29658 CAS #: 67909-49-3 Purity ≥ 99%

Description: Dehydroevodiamine is a naturally occurring quinazoline alkaloid isolated from the unripe fruit of Evodia rutaecarpa (Rutaceae) with a variety of biological effects such as hypotensive, negative chronotropic, ion channel depressa.

References: Loh SH, et al. Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes. J Ethnopharmacol. 2014 May 14;153(3):753-62.

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Molecular Weight (MW)301.34
Molecular FormulaC19H15N3O
CAS No.67909-49-3
SynonymsDehydroevodiamine
ProtocolIn VitroDehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3185 mL16.5926 mL33.1851 mL66.3702 mL
5mM0.6637 mL3.3185 mL6.6370 mL13.2740 mL
10mM0.3319 mL1.6593 mL3.3185 mL6.6370 mL
20mM0.1659 mL0.8296 mL1.6593 mL3.3185 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.