Decoyinine | CAS 2004-04-8

Decoyinine

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Size	Price	Stock
2mg	$150	3-6 Days
5mg	$250	3-6 Days
10mg	$450	3-6 Days
25mg	$750	3-6 Days
50mg	$1250	3-6 Days

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Cat #: V3339 CAS #: 2004-04-8 Purity ≥ 98%

Description: Decoyinine (also known as Angustmycin A) is a potent and selective inhibitor of GMP synthetase (GMPS, guanosine monophosphate synthase). Decoyinine allows sporulation in Bacillus subtilis to initiate and proceed under otherwise catabolite-repressing conditions. Decoyinine did not overcome catabolite repression of alpha-amylase synthesis in a wild-type strain of B. subtilis but did cause premature and enhanced synthesis in a mutant strain specifically blocked in catabolite repression of alpha-amylase synthesis. Decoyinine had no effect on alpha-amylase enzymatic activity. Thus, it appears that the catabolite control mechanisms governing alpha-amylase synthesis and sporulation in B. subtilis differ in their responses to decoyinine and hence must consist at least partially of separate components.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	279.26
Molecular Formula	C11H13N5O4
CAS No.	2004-04-8
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
SMILES Code	NC1=C2C(N(C(C(O)C3O)(CO)OC3=C)C=N2)=NC=N1
Synonyms	Decoyinine; Angustmycin A; Antibiotic A 14

Related Biological Data

GMPS is upregulated during melanoma progression. Cell Death Differ. 2015 Nov;22(11):1858-64.

Angustmycin A treatment affects melanoma invasion in vitro and xenograft growth in vivo. Cell Death Differ. 2015 Nov;22(11):1858-64.

GMPS contributes to the invasive capability of melanoma cells. Cell Death Differ. 2015 Nov;22(11):1858-64.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.5809 mL	17.9045 mL	35.8089 mL	71.6178 mL
5mM	0.7162 mL	3.5809 mL	7.1618 mL	14.3236 mL
10mM	0.3581 mL	1.7904 mL	3.5809 mL	7.1618 mL
20mM	0.1790 mL	0.8952 mL	1.7904 mL	3.5809 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.