Darusentan
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $950 | To Be Confirmed |
| 250mg | $1800 | To Be Confirmed |
| 500mg | $2700 | To Be Confirmed |
: Cat #: V2747 CAS #: 171714-84-4 Purity ≥ 98%
Description: Darusentan (formerly LU-135252 or HMR-4005) is an endothelin receptor antagonist (ERA)/inhibitor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 410.43 |
|---|---|
| Molecular Formula | C22H22N2O6 |
| CAS No. | 171714-84-4 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMrr |
| Water: < 1 mg/mLrr | |
| Ethanol: < 1 mg/mL | |
| SMILES Code | O=C(O)[C@@H](OC1=NC(OC)=CC(OC)=N1)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3 |
| Synonyms | HMR-4005; HMR 4005; HMR4005; Lu 135252; Lu-135252; Lu135252; Darusentan |
| Protocol | In Vivo | Darusentan (30 mg/kg per day orally for weeks 3 and 4) reverses aortic alterations produced by infusion of Norepinephrine (2.5 μg/kg per min subcutaneously for 2 and 4 weeks) in male Sprague Dawley rats |
|---|---|---|
| Animal model | Twenty-four (eight per group) male Sprague Dawley rats weighing 175±200 g | |
| Dosages | 30 mg/kg | |
| Administration | Administered orally in rat food for weeks 3 and 4 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4365 mL | 12.1823 mL | 24.3647 mL | 48.7294 mL |
| 5mM | 0.4873 mL | 2.4365 mL | 4.8729 mL | 9.7459 mL |
| 10mM | 0.2436 mL | 1.2182 mL | 2.4365 mL | 4.8729 mL |
| 20mM | 0.1218 mL | 0.6091 mL | 1.2182 mL | 2.4365 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.