Daidzein
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $175 | Check With Us |
| 100g | $850 | Check With Us |
| 200g | $1275 | Check With Us |
: Cat #: V2124 CAS #: 486-66-8 Purity ≥ 98%
Description: Daidzein is a naturally occuring isoflavone phytoestrogen isolated from Leguminosae, used as a component of foods and dietary supplements.
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| Molecular Weight (MW) | 254.24 |
|---|---|
| Molecular Formula | C15H10O4 |
| CAS No. | 486-66-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 51 mg/mL (200.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Chemical Name: 4',7-Dihydroxyisoflavone InChi Key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N InChi Code: InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H SMILES Code: O=C1C(C2=CC=C(O)C=C2)=COC3=C1C=CC(O)=C3 |
| Synonyms | Daidzein; Daidzeol; Isoaurostatin |
| Protocol | In Vitro | Daidzein is a soy isoflavone that upregulates Abcg1 expression and promotes axon growth in cultured hippocampal neurons through estrogen receptor signaling. Daidzein is the main component of soybeans and has a structure similar to estrogen. It exerts anti-inflammatory effects, reduces lipid levels, and increases mitochondrial biosynthesis. As an activator of the nuclear receptor peroxisome proliferator-activating receptor (PPAR), daidzein enhances the transcription of PPAR-dependent genes, including the hepatic X receptor (LXR, Nr1h gene family in mice). Incubation with 5 to 100 μM of Daidzein at different concentrations increases APOE transcriptional activity. |
|---|---|---|
| In Vivo | Treatment of Apoe KO mice with daidzein increased Lxr and Abca1 gene expression 1 month after stroke, indicating that deletion of ApoE does not interfere with other cholesterol homeostatic genetic programs. Therefore, the findings suggest that Daidzein-induced upregulation of ApoE is a key factor in promoting functional recovery in patients with chronic stroke. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9333 mL | 19.6665 mL | 39.3329 mL | 78.6658 mL |
| 5mM | 0.7867 mL | 3.9333 mL | 7.8666 mL | 15.7332 mL |
| 10mM | 0.3933 mL | 1.9666 mL | 3.9333 mL | 7.8666 mL |
| 20mM | 0.1967 mL | 0.9833 mL | 1.9666 mL | 3.9333 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.