Cytarabine hydrochloride (MK-8242)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $230 | Check With Us |
| 100g | $390 | Check With Us |
| 200g | $585 | Check With Us |
: Cat #: V19037 CAS #: 69-74-9 Purity ≥ 99%
Description: Cytarabine hydrochloride (MK-8242; SCH-900242; AC-1075; CHX-3311; Arabitin), the hydrochloride salt of cytarabine, is a pyrimidine nucleoside analog and antimetabolic anticancer agent with a modified sugar moiety.
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| Molecular Weight (MW) | 279.68 |
|---|---|
| Molecular Formula | C9H14ClN3O5 |
| CAS No. | 69-74-9 |
| Protocol | In Vitro | Cytarabine is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5755 mL | 17.8776 mL | 35.7551 mL | 71.5103 mL |
| 5mM | 0.7151 mL | 3.5755 mL | 7.1510 mL | 14.3021 mL |
| 10mM | 0.3576 mL | 1.7878 mL | 3.5755 mL | 7.1510 mL |
| 20mM | 0.1788 mL | 0.8939 mL | 1.7878 mL | 3.5755 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.