Cytarabine

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$380	Check With Us
10g	$620	Check With Us
20g	$930	Check With Us

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Cat #: V1459 CAS #: 147-94-4 Purity ≥ 98%

Description: Cytarabine (formerly Ara-C; MK-8242; SCH-900242; SCH900242; MK8242; AC-1075; CHX 3311; Arabitin; Aracytidine), a pyrimidine nucleoside analog approved for cancer treatment, is an antimetabolite anticancer drug used mainly for treating leukemia.

References: Tobias, S.C. and R.F. Borch, Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm, 2004. 1(2): p. 112-6.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	243.22
Molecular Formula	C9H13N3O5
CAS No.	147-94-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: <1 mg/mLr
	Water: 48 mg/mL (197.4 mM)r
	Ethanol: <1 mg/mL
Solubility In Vivo	Saline: 30 mg/mL
Synonyms	Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C; MK-8242; SCH-900242; MK 8242; SCH900242; MK8242; SCH 900242; AC-1075; CHX 3311, MK 8242; NCI-C04728; NSC 287459; Cytosine arabinose; Arabitin; Aracytidine

Protocol	In Vitro	Cytarabine is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.1115 mL	20.5575 mL	41.1150 mL	82.2301 mL
5mM	0.8223 mL	4.1115 mL	8.2230 mL	16.4460 mL
10mM	0.4112 mL	2.0558 mL	4.1115 mL	8.2230 mL
20mM	0.2056 mL	1.0279 mL	2.0558 mL	4.1115 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.