Cyclobenzaprine HCl (MK-130)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$330	Check With Us
10g	$550	Check With Us
20g	$825	Check With Us

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Cat #: V1918 CAS #: 6202-23-9 Purity ≥ 98%

Description: Cyclobenzaprine HCl (also known as MK130; Flexeril), the hydrochloride salt of Cyclobenzaprine, is a potent muscle relaxant by blocking pain sensations, used as a medication for the treatment of skeletal muscle spasms and associated pain in acute musculoskeletal conditions.

References: Kobayashi, H., Y. Hasegawa, and H. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311(1): p. 29-35.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	311.85
Molecular Formula	C20H22ClN
CAS No.	6202-23-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 62 mg/mL (198.8 mM)r
	Water: 62 mg/mL (198.8 mM)r
	Ethanol: N/A
Solubility In Vivo	Chemical Name: (Z)-3-(10H-dibenzo[a,d][7]annulen-10-ylidene)-N,N-dimethylpropan-1-amine hydrochloride InChi Key: VJSLSIJWPIOMIP-XHFAFUTOSA-N InChi Code: InChI=1S/C20H21N.ClH/c1-21(2)13-7-11-19-15-17-9-4-3-8-16(17)14-18-10-5-6-12-20(18)19;/h3-6,8-12,14-15H,7,13H2,1-2H3;1H/b19-11-; SMILES Code: CN(C)CC/C=C1C2=CC=CC=C2C=C(C=CC=C3)C3=C1.[H]Cl
Synonyms	MK-130 HCl; Lisseril; Proeptatriene; MK130 hydrochloride; MK 130; Flexeril; Proheptatriene; Proheptatrien

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.2067 mL	16.0333 mL	32.0667 mL	64.1334 mL
5mM	0.6413 mL	3.2067 mL	6.4133 mL	12.8267 mL
10mM	0.3207 mL	1.6033 mL	3.2067 mL	6.4133 mL
20mM	0.1603 mL	0.8017 mL	1.6033 mL	3.2067 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.