Cyamemazine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $900 | To Be Confirmed |
| 250mg | $1750 | To Be Confirmed |
| 500mg | $2625 | To Be Confirmed |
: Cat #: V18922 CAS #: 3546-03-0 Purity ≥ 99%
Description: Cyamemazine (Tercian; Cianatil; cyamepromazine) is a typical antipsychotic drug of the phenothiazine class.
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| Molecular Weight (MW) | 323.46 |
|---|---|
| Molecular Formula | C19H21N3S |
| CAS No. | 3546-03-0 |
| Protocol | In Vitro | Cyamemazine exhibits a high affinity for dopamine receptors, which is consistent with its antipsychotic activity. The antagonist activity of Cyamemazine at muscarinic receptors is consistent with its affinity for M1 (Ki = 13 nM), M2 (Ki = 42 nM), M3 (Ki = 321 nM), M4 (Ki = 12 nM), and M5 (Ki = 35 nM) receptors |
|---|---|---|
| In Vivo | Cyamemazine behaves as an antagonist at the 5-HT3, 5-HT2C, and 5-HT2A receptors in 5-HT3-dependent contraction of isolated guinea pig ileum and bradycardic responses in rats, in 5-HT2C-dependent phospholipase C stimulation in the rat brain membrane, and in 5-HT2A-dependent contraction of isolated rat aorta rings and isolated guinea pig trachea. Cyamemazine antagonizes 5-HT3 and 5-HT2C receptors and that this effect is partially involved in its therapeutic activity in anxiety disorders. Acute administration of low doses of Cyamemazine can reduces extracellular dopamine and metabolite concentrations in rat striatum |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0916 mL | 15.4579 mL | 30.9157 mL | 61.8314 mL |
| 5mM | 0.6183 mL | 3.0916 mL | 6.1831 mL | 12.3663 mL |
| 10mM | 0.3092 mL | 1.5458 mL | 3.0916 mL | 6.1831 mL |
| 20mM | 0.1546 mL | 0.7729 mL | 1.5458 mL | 3.0916 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.