CUDC-427 (GDC-0917)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1200 | Check With Us |
| 250mg | $1920 | Check With Us |
| 500mg | $2880 | Check With Us |
: Cat #: V4532 CAS #: 1446182-94-0 Purity ≥ 98%
Description: CUDC-427 (also known as GDC-0917) is a novel, potent, orally available, second-generation antagonist of inhibitor of apoptosis (IAP) proteins that is being developed for the treatment of various cancers.
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| Molecular Weight (MW) | 564.70 |
|---|---|
| Molecular Formula | C29H36N6O4S |
| CAS No. | 1446182-94-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)CCC1)NC3=C(C4=CC=CC=C4)N=C(C5=NC=CO5)S3 |
| Synonyms | CUDC427; CUDC-427; CUDC 427; GDC0917; GDC-0917; GDC 0917; |
| Protocol | In Vitro | GDC-0917 (0.1 nM-10 μM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 µM (56.5 ng/mL). |
|---|---|---|
| In Vivo | GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7709 mL | 8.8543 mL | 17.7085 mL | 35.4170 mL |
| 5mM | 0.3542 mL | 1.7709 mL | 3.5417 mL | 7.0834 mL |
| 10mM | 0.1771 mL | 0.8854 mL | 1.7709 mL | 3.5417 mL |
| 20mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 1.7709 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.