ASTX660 is a novel and orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptoticctivities.
BV-6 is a novel and potent SMAC (second mitochondrial-derived activator of caspases) mimetic, and a dual inhibitor of cIAP (inhibitor of apoptosis) and XIAP (X-linked inhibitor of apoptosis) with potential anticancer activity.
Embelin is a naturally occuring quinone compound isolated from the Japanese Ardisia herb with anti-tumor and anti-inflammatory activity, acting as a potent and cell-permeable inhibitor of XIAP (X-linked inhibitor of apoptosis) with IC50 of 4.1 μM in cell-free assays.
LCL161 (LCL-161) is a novel and potent SMAC (second mitochondrial-derived activator of caspases) mimetic agent with potential anticancer activity, acting by potently binding to and inhibiting multiple IAP (inhibitor of apoptosis) proteins such as XIAP and c-IAP.
AZD5582 is a novel and potent IAP (Inhibitor of apoptosis proteins) antagonist which binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.
Birinapant (TL32711; TL-32711; TL 32711) is a novel and potent bivalent peptidomimetic of SMAC (second mitochondrial-derived activator of caspases) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins.
CUDC-427 (also known as GDC-0917) is a novel, potent, orally available, second-generation antagonist of inhibitor of apoptosis (IAP) proteins that is being developed for the treatment of various cancers.
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein and binds to cIAP-1 and cIAP-2 proteins.
GDC-0152 (RG-7419) is a novel and potent antagonist of IAP (inhibitor of apoptosis) family proteins with antitumor activity.
Xevinapant (formerly Debio1143; AT-406; SM-406, ARRY-334543) is a first-in-class and orally bioavailable peptidomimetic of SMAC (second mitochondrial-derived activator of caspases)/DIABLO with potential antitumor activity, also an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) proteins.