Cucurbitacin I
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2550 | Check With Us |
| 250mg | $3850 | Check With Us |
| 500mg | $5775 | Check With Us |
: Cat #: V4972 CAS #: 2222-07-3 Purity ≥ 98%
Description: Cucurbitacin I, a naturally occurring triterpene analog, is a novel, potent and selective inhibitor of JAK2/STAT3 with potent anti-cancer activity on a variety of cancer cell types. autophagy and apoptosis were induced by cucurbitacin I.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 514.65 |
|---|---|
| Molecular Formula | C30H42O7 |
| CAS No. | 2222-07-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(C(C)(C)C1=CC[C@@]2([H])[C@]3(C)C[C@@H](O)[C@H]([C@](C(/C=C/C(C)(O)C)=O)(O)C)[C@@]3(C)C4)C(O)=C[C@@]1([H])[C@]2(C)C4=O |
| Synonyms | Cucurbitacin I; Elatericin B; JSI-124; JSI 124; JSI124; NSC 521777; NSC-521777; NSC521777; |
| Protocol | In Vitro | Exposure of the COLO205 cells to Cucurbitacin I significantly decreases cell viability. The anticancer activity of Cucurbitacin I is accomplished by downregulating p-STAT3 and MMP-9 expression. |
|---|---|---|
| In Vivo | No major side effects are noted throughout the study. It is shown that average tumor volumes at the end of the study are as follows: control, 616 mm3 (±130); CQ, 580 mm3 (±107); Cucurbitacin I, 346mm3 (±79); and combination, 220mm3 (±62). The differences in tumor volume between the Cucurbitacin I and control, combination and control, and combination and Cucurbitacin I arms are significant. Furthermore, combination-treated tumors exhibit a significantly lower average tumor weight at study termination than the control. Moreover, there was no effect on the body weights of mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9431 mL | 9.7153 mL | 19.4307 mL | 38.8614 mL |
| 5mM | 0.3886 mL | 1.9431 mL | 3.8861 mL | 7.7723 mL |
| 10mM | 0.1943 mL | 0.9715 mL | 1.9431 mL | 3.8861 mL |
| 20mM | 0.0972 mL | 0.4858 mL | 0.9715 mL | 1.9431 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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Concentration(final)
C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.