CU-CPT-9b
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1500 | Check With Us |
| 500mg | $2250 | Check With Us |
| 1g | $3375 | Check With Us |
: Cat #: V3817 CAS #: 2162962-69-6 Purity ≥ 98%
Description: CU-CPT-9b, an analog of CU-CPT-8m and CU-CPT-9a, is a specific antagonist of TLR8 (Toll-like receptor 8) with IC50 of 0.7 nM.
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| Molecular Weight (MW) | 251.28 |
|---|---|
| Molecular Formula | C16H13NO2 |
| CAS No. | 2162962-69-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water:<1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | OC1=CC=C2C(C3=CC=C(O)C(C)=C3)=CC=NC2=C1 |
| Synonyms | CU-CPT9b; CUCPT9b; CU CPT9b |
| Protocol | In Vitro | CU-CPT9b is a specific TLR8 antagonist, with an IC50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT9b with a Kd of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT9b as compared to TLR8/CU-CPT8m. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9796 mL | 19.8981 mL | 39.7962 mL | 79.5925 mL |
| 5mM | 0.7959 mL | 3.9796 mL | 7.9592 mL | 15.9185 mL |
| 10mM | 0.3980 mL | 1.9898 mL | 3.9796 mL | 7.9592 mL |
| 20mM | 0.1990 mL | 0.9949 mL | 1.9898 mL | 3.9796 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.