CU-CPT-9a
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1550 | Check With Us |
| 500mg | $2350 | Check With Us |
| 1g | $3525 | Check With Us |
: Cat #: V3816 CAS #: 2165340-32-7 Purity ≥ 98%
Description: CU-CPT-9a, an analog of CU-CPT-8m, is a potent and specific antagonist/inhibitor of TLR8 (Toll-like receptor 8) (IC50 = 0.5 nM) with the potential to be used for treating autoimmune diseases.
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| Molecular Weight (MW) | 265.31 |
|---|---|
| Molecular Formula | C17H15NO2 |
| CAS No. | 2165340-32-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >30 mg/mLr |
| Water:<1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | OC1=CC=C(C2=CC=NC3=CC(OC)=CC=C23)C=C1C |
| Synonyms | CU-CPT9a; CUCPT9a; CU CPT9a |
| Protocol | In Vitro | CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7692 mL | 18.8459 mL | 37.6918 mL | 75.3835 mL |
| 5mM | 0.7538 mL | 3.7692 mL | 7.5384 mL | 15.0767 mL |
| 10mM | 0.3769 mL | 1.8846 mL | 3.7692 mL | 7.5384 mL |
| 20mM | 0.1885 mL | 0.9423 mL | 1.8846 mL | 3.7692 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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