COPANLISIB HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$770	Check With Us
500mg	$1250	Check With Us
1g	$1875	Check With Us

: [email protected] [email protected]

Cat #: V3911 CAS #: 1402152-13-9 Purity ≥ 98%

Description: Copanlisib HCl (formerly BAY-806946; BAY 80-6946; Aliqopa), the hydrochloride salt of Copanlisib, is a pan-class I PI3K (phosphoinositide 3-kinase) inhibitor approved in 2017 for the treatment of relapsed follicular lymphoma.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	553.45
Molecular Formula	C23H30Cl2N8O4
CAS No.	1402152-13-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMr
	Water:<1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	10% Trifluoroacetic acid water solution: 1mg/mL
SMILES Code	O=C(C1=CN=C(N)N=C1)NC2=NC3=C(C=CC(OCCCN4CCOCC4)=C3OC)C5=NCCN25.[H]Cl.[H]Cl
Synonyms	BAY 80-6946 2HCl; BAY806946 dihydrochloride; BAY80-6946; BAY-80-6946; BAY-806946; BAY 806946 dihydrochloride

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8068 mL	9.0342 mL	18.0685 mL	36.1370 mL
5mM	0.3614 mL	1.8068 mL	3.6137 mL	7.2274 mL
10mM	0.1807 mL	0.9034 mL	1.8068 mL	3.6137 mL
20mM	0.0903 mL	0.4517 mL	0.9034 mL	1.8068 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.