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CM11 (Homo-PROTAC)

This product is for research use only, not for human use. We do not sell to patients.

CM11 (Homo-PROTAC)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$2350In Stock
1g$3000In Stock
5g$7595In Stock
email: [email protected]        [email protected]

Cat #: V17301 CAS #: 2244684-49-7 Purity ≥ 98%

Description: CM11 is a PROTAC molecule that acts as a novel and potent VHL inhibitor which induces complete degradation/depletion of pVHL30.

References: Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.

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Molecular Weight (MW)1179.45
Molecular FormulaC58H82N8O14S2
CAS No.2244684-49-7
SMILES CodeO=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O
SynonymsCM11, Homo-PROTAC, CM-11
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM0.8479 mL4.2393 mL8.4785 mL16.9571 mL
5mM0.1696 mL0.8479 mL1.6957 mL3.3914 mL
10mM0.0848 mL0.4239 mL0.8479 mL1.6957 mL
20mM0.0424 mL0.2120 mL0.4239 mL0.8479 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.