Cladribine | CAS 4291-63-8

Cladribine

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Size	Price	Stock
500mg	$350	Check With Us
1g	$550	Check With Us
5g	$1480	Check With Us

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Cat #: V1456 CAS #: 4291-63-8 Purity ≥ 98%

Description: Cladribine (also known as 2-CdA, 2-chlorodeoxyadenosine; Leustatin; Leustat; Leustatine), a purine nucleoside antimetabolite analogue and an approved medication used for treating hairy cell leukemia and B-cell chronic lymphocytic leukemia, is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50s of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

References: Young Seop Chang, et al. MP28-10 COMBINED EFFECTS OF MELATONIN AND CLADRIBINE ON APOPTOSIS IN ISCHEMIA/REPERFUSION INJURY IN RAT BLADDER. THE JOURNAL OF UROLOGY. April 2016. 195 (4S): e375.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	285.69
Molecular Formula	C10H12ClN5O3
CAS No.	4291-63-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 57 mg/mL (199.5 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA; 2-CdA, 2-chlorodeoxyadenosine; Cladribina. Trade name: Leustatin; Leustat; Leustatine.

Protocol	In Vivo	Cladribine (10 μg/kg; i.p.; 3 times/week; for 2 weeks) may have benefits in the treatment of ischemia/reperfusion injury to the biochemical and histopathologic parameters
	Animal model	Male Sprague-Dawley rats, ischemic injury model
	Dosages	10 μg/kg
	Administration	Intraperitoneal injection, 3 times/week, for 2 weeks

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.5003 mL	17.5015 mL	35.0030 mL	70.0060 mL
5mM	0.7001 mL	3.5003 mL	7.0006 mL	14.0012 mL
10mM	0.3500 mL	1.7501 mL	3.5003 mL	7.0006 mL
20mM	0.1750 mL	0.8751 mL	1.7501 mL	3.5003 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.