Cinacalcet metabolite M4

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
5g	$450	To Be Confirmed
10g	$750	To Be Confirmed
20g	$1125	To Be Confirmed

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Cat #: V37799 CAS #: 104774-87-0 Purity ≥ 99%

Description: Cinacalcet metabolite M4 is a metabolite of Cinacalcet (AMG-073; KRN-1493; Regpara; Sensipar; Mimpara), which is allosteric agonist of Ca receptor (CaR) approved as a medication for the treatment of hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism.

References: Kumar GN, et al. Metabolism and disposition of calcimimetic agent cinacalcet HCl in humans and animalmodels. Drug Metab Dispos. 2004 Dec;32(12):1491-500.

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Molecular Weight (MW)	203.20
Molecular Formula	C10H12F3N
CAS No.	104774-87-0
Synonyms	Cinacalcet metabolite M4

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.9213 mL	24.6063 mL	49.2126 mL	98.4252 mL
5mM	0.9843 mL	4.9213 mL	9.8425 mL	19.6850 mL
10mM	0.4921 mL	2.4606 mL	4.9213 mL	9.8425 mL
20mM	0.2461 mL	1.2303 mL	2.4606 mL	4.9213 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.