Cetilistat (ATL-962)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $110 | Check With Us |
| 5g | $180 | Check With Us |
| 10g | $270 | Check With Us |
: Cat #: V3147 CAS #: 282526-98-1 Purity ≥ 98%
Description: Cetilistat (previously known as ATL-962) is a novel inhibitor of pancreatic and gastrointestinal lipases.
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| Molecular Weight (MW) | 401.58 |
|---|---|
| Molecular Formula | C25H39NO3 |
| CAS No. | 282526-98-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 3 mg/mL (7.5 mM)r |
| Water: < 1 mg/mLr | |
| Ethanol: 9 mg/mL (20 mM) | |
| SMILES Code | CC1=CC=C(N=C(OCCCCCCCCCCCCCCCC)OC2=O)C2=C1 |
| Synonyms | ATL962; ATL-962; ATL 962 |
| Protocol | In Vitro | Cetilistat inhibits rat pancreatic lipase activity with an IC50 of 54.8 nM. Also, Cetilistat inhibits human pancreatic lipase activity with an IC50 of 5.95 nM, which is 9.2 times more potent than for rat pancreatic lipase. |
|---|---|---|
| In Vivo | Cetilistat (4.9, 14.9, or 50.7 mg/kg; mixed into powdered high-fat diet; once a day; for three weeks) shows anti-obesity and antihyperlipidemic effects on DIO F344 rats by reducing intestinal fat absorption. Cetilistat (3, 10, 30, or 100 mg/kg) reduces intestinal fat absorption by inhibiting pancreatic lipase activity in male SD rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4902 mL | 12.4508 mL | 24.9016 mL | 49.8033 mL |
| 5mM | 0.4980 mL | 2.4902 mL | 4.9803 mL | 9.9607 mL |
| 10mM | 0.2490 mL | 1.2451 mL | 2.4902 mL | 4.9803 mL |
| 20mM | 0.1245 mL | 0.6225 mL | 1.2451 mL | 2.4902 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.