Celecoxib (SC 58635)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$450	Check With Us
10g	$700	Check With Us
20g	$1050	Check With Us

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Cat #: V1038 CAS #: 169590-42-5 Purity ≥ 98%

Description: Celecoxib (formerly SC58635; YM-177; SC-58635; YM 177; trade name Celebrex; Xilebao), an anti-inflammatory agent of the NSAID class, is a potent and selective COX-2 inhibitor of the non-steroidal anti-inflammatory drug (NSAID) class with an IC50 of 40 nM in Sf9 cells.

References: Liu DB, et al. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta Pharmacol Sin. 2012 May;33(5):682-90.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	381.37
Molecular Formula	C17H14F3N3O2S
CAS No.	169590-42-5
Storage	-20℃ for 3 years in powder formrrrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 76 mg/mL (199.3 mM)rrrr
	Water: <1 mg/mLrrrr
	Ethanol: 33 mg/mL (86.5 mM)
Solubility In Vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 5mg/mL
Synonyms	SC 58635; YM177. Celecoxib; SC58635; YM-177; SC-58635; YM 177; trade name Celebrex; Xilebao.

Protocol	In Vitro	The selective cyclooxygenase-2 (COX-2) inhibitor Celecoxib (10-75 μM) inhibits the proliferation of the NPC cell lines in a dose-dependent manner. Celecoxib (25 and 50 μM) induces apoptosis and cell-cycle arrest at the G0/G1 checkpoint in the NPC cell lines, which is associated with significantly reduced STAT3 phosphorylation. The genes downstream of STAT3 (ie, Survivin, Mcl-1, Bcl-2 and Cyclin D1) are significantly down-regulated after exposure to Celecoxib (25 and 50 μM)

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6221 mL	13.1106 mL	26.2213 mL	52.4425 mL
5mM	0.5244 mL	2.6221 mL	5.2443 mL	10.4885 mL
10mM	0.2622 mL	1.3111 mL	2.6221 mL	5.2443 mL
20mM	0.1311 mL	0.6555 mL	1.3111 mL	2.6221 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.