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Capsaicin ((E)-Capsaicin)

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Capsaicin ((E)-Capsaicin)
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Cat #: V17503 CAS #: 404-86-4 Purity ≥ 98%

Description: Capsaicin ((E)-Capsaicin), a mixture of Capsaicin and Dihydrocapsaicin, is an active component isolatedd from chili peppers, which are plants belonging to the genus Capsicum, acting as a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.

References: Krishnapura Srinivasan. Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review. Crit Rev Food Sci Nutr. 2016 Jul 3;56(9):1488-500.

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Molecular Weight (MW)305.41
Molecular FormulaC18H27NO3
CAS No.404-86-4
SMILES CodeCC(C)/C=C/CCCCC(NCC1=CC=C(O)C(OC)=C1)=O 
ProtocolIn VitroCapsaicin is the main Capsaicinoid in chili peppers, followed by Dihydrocapsaicin. These two compounds provide about twice hotness to the taste and nerves as the minor capsaicinoids
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.2743 mL16.3714 mL32.7429 mL65.4857 mL
5mM0.6549 mL3.2743 mL6.5486 mL13.0971 mL
10mM0.3274 mL1.6371 mL3.2743 mL6.5486 mL
20mM0.1637 mL0.8186 mL1.6371 mL3.2743 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.